NN1177 TFA 产品活性：NN1177 (NNC9204-1177) TFA 是一种长效 GLP-1/胰高血糖素受体 共激动剂。NN1177 TFA 可诱导饮食诱导肥胖 (DIO) 小鼠出现剂量依赖性体重减轻。 产品来源： https://www.medchemexpress.cn/nn1177-tfa.html 研究领域：GPCR/G Protein | Metabolic Enzyme/Protease 作用靶点：GCGR | Cytochrome P450 | GLP Receptor In Vitro: NN1177 (100 nM, 3 days) TFA reduces CYP3A4 mRNA expression (57.2-71.7%) and activity (18.5-51.5%) in freshly isolated human hepatocytes. In Vivo: NN1177 (3 or 5 nmol/kg, s.c.) TFA induces body weight loss, loss of fat mass, and improvement in glucose tolerance in diet-induced obese (DIO) mice. NN1177 (0.75-4 nmol/kg, s.c., once daily, 8 weeks) TFA reduces liver fat and inflammatory and fibrosis relevant biomarkers in C57Bl/6 mice fed a fructose and high fat rich diet (NASH model). 相关产品：Semaglutide | Exendin-4 | Verapamil | Liraglutide | Tirzepatide hydrochloride | Apigenin | Fenofibrate | Chlorpromazine hydrochloride | Glucagon (1-29), bovine, human | Exendin(9-39) amide | Ketoconazole | Abiraterone | Letrozole | 1-Aminobenzotriazole | Itraconazole | Retatrutide | Cepharanthine | Quinidine (15% dihydroquinidine) | Clarithromycin | Atovaquone | Diosmetin | Gemfibrozil 1-O-β-glucuronide | Naringin | Fomepizole | Orforglipron | GLP-1(7-37) 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。