耗材描述
TRAP-14
产品活性:TRAP-14 (SFLLRNPNDKYEPF) 是人工合成的 thrombin 受体激动剂肽段。
产品来源: https://www.medchemexpress.cn/Sfllrnpndkyepf.html
研究领域:Metabolic Enzyme/Protease
作用靶点:Thrombin
In Vitro: Thrombin cleaves its receptor at arginine-41, resulting in the generation of a new receptor NH2-terminus with the sequence TRAP-14. This peptide (TRAP-14) may signal a variety of thrombin's responses. TRAP-14, representing the 14 amino acids starting with Ser-42 of the human thrombin receptor, was found to mimic the effect of thrombin on platelets. Cleavage of the human platelet thrombin receptor by thrombin exposes a new N-terminal which acts as a putative tethered ligand. TRAP-14, corresponding to the new N-terminal region, activates and induces platelet aggregation and serotonin secretion. TRAP-14 is the minimal peptide length which retains full activity in inducing [14C]serotonin secretion. TRAP induces rapid morphological changes in HUVECs, with marked increase in the release of prostacyclin, endothelin, platelet activating factor, tissue type plasminogen activator, and plasminogen activator inhibitor-1. Incubation of cells with TRAP also induces a rapid decrease in cell-surface thrombomodulin.
相关产品:Bioactive Compound Library Plus | Peptide Library | Heparin sodium salt | AEBSF hydrochloride | Protamine sulfate | Thrombin (MW 37kDa) | Dabigatran | Edoxaban | Argatroban monohydrate | Bivalirudin TFA | Metolazone | Enoxaparin | Hirudin | Ximelagatran | Dabigatran ethyl ester hydrochloride | NQ301 | Human α-Thrombin | Melagatran | Dermatan sulphate sodium | Odiparcil | TP508 TFA
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