TRAP-14 | MedChemExpress (MCE)

TRAP-14 产品活性：TRAP-14 (SFLLRNPNDKYEPF) 是人工合成的 thrombin 受体激动剂肽段。 产品来源： https://www.medchemexpress.cn/Sfllrnpndkyepf.html 研究领域：Metabolic Enzyme/Protease 作用靶点：Thrombin In Vitro: Thrombin cleaves its receptor at arginine-41, resulting in the generation of a new receptor NH2-terminus with the sequence TRAP-14. This peptide (TRAP-14) may signal a variety of thrombin's responses. TRAP-14, representing the 14 amino acids starting with Ser-42 of the human thrombin receptor, was found to mimic the effect of thrombin on platelets. Cleavage of the human platelet thrombin receptor by thrombin exposes a new N-terminal which acts as a putative tethered ligand. TRAP-14, corresponding to the new N-terminal region, activates and induces platelet aggregation and serotonin secretion. TRAP-14 is the minimal peptide length which retains full activity in inducing [14C]serotonin secretion. TRAP induces rapid morphological changes in HUVECs, with marked increase in the release of prostacyclin, endothelin, platelet activating factor, tissue type plasminogen activator, and plasminogen activator inhibitor-1. Incubation of cells with TRAP also induces a rapid decrease in cell-surface thrombomodulin. 相关产品：Bioactive Compound Library Plus | Peptide Library | Heparin sodium salt | AEBSF hydrochloride | Protamine sulfate | Thrombin (MW 37kDa) | Dabigatran | Edoxaban | Argatroban monohydrate | Bivalirudin TFA | Metolazone | Enoxaparin | Hirudin | Ximelagatran | Dabigatran ethyl ester hydrochloride | NQ301 | Human α-Thrombin | Melagatran | Dermatan sulphate sodium | Odiparcil | TP508 TFA 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途