Galantide 产品活性：Galantide 是一种特殊的甘丙肽受体 (galanin receptor) 拮抗剂，是一种由甘丙肽和 P 物质片段组成的肽段，在大鼠下丘脑可识别两类甘丙肽结合位点 (KD 分别小于 0.1 nM 和 ~6 nM)。Galantide 剂量依赖性 (IC50=1.0 nM) 拮抗甘丙肽介导的葡萄糖诱导的小鼠胰岛胰岛素分泌抑制。Galantide 似乎与单一的 SP 受体群结合 (KD~40 nM)。 产品来源： https://www.medchemexpress.cn/Galantide.html 研究领域：GPCR/G Protein | Neuronal Signaling 作用靶点：Neuropeptide Y Receptor In Vitro: Galantide do not activate the K+ conductance but produces a concentration-dependent antagonism (IC50=4 nM) of the galanin-induced increase in K+ conductance. Galantide acts like galanin and inhibits the voltage-dependent Ba2+ current (IBa). The inhibition of IBa also is concentration dependent (IC50=16 nM) and the maximum inhibition produced by galantide is approximately 40%. In Vivo: Intracerebroventricular injection of galanin (5 micrograms/rat) inhibited sexual behavior in experienced male rats--without producing any other locomotor or behavioral deficit-, injection of the galanin antagonist, galantide, by the same route (1 or 2 micrograms/rat) stimulated sexual behavior (improving arousal, motivation and performance indexes) and antagonized the effect of galanin. Galantide ameliorates mild acute pancreatitis (AP). Galantide significantly reduces AP-induced hyperenzymemia by 41–49%. Galantide has been found to improve social memory in 'socialrecognition' test when i.c.v. administered at doses varying from 6-6000 nM. 相关产品：BIBO3304 TFA | Galanin (1-30), human | HT-2157 | SHA 68 | Spexin | MK-0557 | BIIE-0246 | Neuropeptide Y (human,rat,mouse) (TFA) | BIBP3226 TFA | Galanin Receptor Ligand M35 | JNJ-31020028 | CGP71683 hydrochloride | [Leu31,Pro34]-Neuropeptide Y(human,rat,mouse) TFA | L 152804 | Pancreatic Polypeptide, human | RF9 | BMS-193885 | Neuropeptide Y (3-36) (human, rat) | Peptide YY (PYY) (3-36), porcine TFA | RFRP-3(human) | Peptide YY (PYY), human | Velneperit | CYM 9484 | Galnon TFA | [Leu31,Pro34]-Neuropeptide Y (porcine) | CART(55-102)(human) | M871 | Neuropeptide S(Mouse) | Peptide YY (PYY) (3-36), Human 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。