Rapanone 产品活性：Rapanone 是一种天然苯醌。Rapanone 具有广泛的生物作用，包括抗肿瘤、抗氧化、抗炎、抗菌和抗寄生虫。Rapanone 还是一种有效和选择性的人滑膜 PLA2 抑制剂，IC50 值为 2.6 μM。 产品来源： https://www.medchemexpress.cn/rapanone.html 研究领域：Apoptosis | Metabolic Enzyme/Protease | Anti-infection 作用靶点：Apoptosis | Phospholipase | Bacterial | Parasite 来源：植物 | 紫金牛科 | 酸藤子 结构分类：醌类 | 苯醌类 In Vitro: Rapanone (10-40 μM; 24 h) inhibits the cell viability, with IC50s of 35.58 μM and 27.89 μM for primary rats hepatocytes and HepG2 cells, respectively. Rapanone (10-40 μM; 24 h) induces a concentration-dependent mitochondrial membrane potential dissipation, ATP depletion, hydrogen peroxide generation and, phosphatidyl serine externalization in HepG2 cells. Rapanone inhibits electron transport at Complex III and promotes mitochondrial dysfunction. In Vivo: Rapanone (2.5-10 mg/kg; i.p.) exhibits anti-inflammatory effects in the carrageenan paw oedema model in mice. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Apoptosis Compound Library | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | Natural Product Library | Anti-Cancer Compound Library | Antioxidant Compound Library | Lipid Compound Library | Antibacterial Compound Library | Traditional Chinese Medicine Active Compound Library | Antiparasitic Compound library | Lipid Metabolism Compound Library | Anti-Cancer Natural Product Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Metabolic Enzyme Compound Library | Highly Selective Inhibitors Library | Highly Selective Activators Library | Cell Death Library | Multi-Target Compound Library | Radioprotector Library | Bioactive Compound Library Max | MG-132 | Rapamycin | Chloroquine | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Dimethyl sulfoxide | Y-27632 | LY294002 | Paclitaxel | Dexamethasone | Z-VAD-FMK | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Puromycin dihydrochloride | Staurosporine | Actinomycin D | SB-431542 | 5-Fluorouracil | Bortezomib | Deferoxamine mesylate | Oxaliplatin | Trametinib | Sorafenib | Temozolomide | Gemcitabine | Decitabine | Mdivi-1 | Rotenone 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。