耗材描述
Randialic acid B
产品活性:Randialic acid B 是一种三萜化合物,是一种甲酰肽受体 1 (FPR1) 拮抗剂。Randialic acid B 阻断人中性粒细胞中的 FPR1 并在体内减轻银屑病样炎症。
产品来源: https://www.medchemexpress.cn/randialic-acid-b.html
研究领域:Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease
作用靶点:Reactive Oxygen Species
来源:植物 | 冬青科 | 毛冬青
结构分类:萜类 | 三萜
In Vitro: Randialic acid B (0.1-3 μM; for 5 min) selectively inhibits reactive oxygen species production, elastase release, and CD11b expression in human neutrophils activated by FPR1. Randialic acid B inhibits the binding of N-formyl peptide to FPR1 in human neutrophils, neutrophil-like THP-1 cells, and hFPR1-transfected HEK293 cells, indicating FPR1 antagonism.
Randialic acid B acts competitively for its binding to the FPR1 receptor. The FPR1-downstream signaling such as Ca2+ mobilisation and activation of Akt and MAPKs is also competitively inhibited.
Randialic acid B shows significant cell-protective effects against H2O2-induced H9c2 cardiomyocyte injury.
In Vivo: Randialic acid B (10 mg/kg; i.v.; every other day; for 5 days) significantly reduces Imiquimod-induced psoriasis-like symptom, including epidermal hyperplasia, desquamation with scaling, neutrophil skin infiltration, and transepidermal water loss.
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