Randialic acid B | MedChemExpress (MCE)

Randialic acid B 产品活性：Randialic acid B 是一种三萜化合物，是一种甲酰肽受体 1 (FPR1) 拮抗剂。Randialic acid B 阻断人中性粒细胞中的 FPR1 并在体内减轻银屑病样炎症。 产品来源： https://www.medchemexpress.cn/randialic-acid-b.html 研究领域：Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease 作用靶点：Reactive Oxygen Species 来源：植物 | 冬青科 | 毛冬青 结构分类：萜类 | 三萜 In Vitro: Randialic acid B (0.1-3 μM; for 5 min) selectively inhibits reactive oxygen species production, elastase release, and CD11b expression in human neutrophils activated by FPR1. Randialic acid B inhibits the binding of N-formyl peptide to FPR1 in human neutrophils, neutrophil-like THP-1 cells, and hFPR1-transfected HEK293 cells, indicating FPR1 antagonism. Randialic acid B acts competitively for its binding to the FPR1 receptor. The FPR1-downstream signaling such as Ca2+ mobilisation and activation of Akt and MAPKs is also competitively inhibited. Randialic acid B shows significant cell-protective effects against H2O2-induced H9c2 cardiomyocyte injury. In Vivo: Randialic acid B (10 mg/kg; i.v.; every other day; for 5 days) significantly reduces Imiquimod-induced psoriasis-like symptom, including epidermal hyperplasia, desquamation with scaling, neutrophil skin infiltration, and transepidermal water loss. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Acetylcysteine | H2DCFDA | Deferoxamine mesylate | MitoSOX Red | Elesclomol | Quercetin | L-Ascorbic acid | Mito-TEMPO | Mitoquinone mesylate | Sulforaphane | L-Glutathione reduced | Trolox | Dimethyl fumarate | Zinc Protoporphyrin | FX-11 | Diphenyleneiodonium chloride | Urolithin A | Sodium dichloroacetate | Berberine chloride | TPEN | α-Vitamin E | Ciprofloxacin | 2-Methoxyestradiol | Coenzyme Q10 | Tempol | GSK2795039 | Trabectedin | Chlorogenic acid | Uric acid | Gallic acid 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

Randialic acid B | MedChemExpress (MCE)信息由MedChemExpress (MCE)为您提供，如您想了解更多关于Randialic acid B | MedChemExpress (MCE)报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途