耗材描述
Rabdosin B
产品活性:Rabdosin B,一种 ent-kaurene 二萜类化合物,具有抗癌作用。Rabdosin B 在细胞中诱导 DNA 损伤,并抑制幼苗生菜根毛的发育。
产品来源: https://www.medchemexpress.cn/rabdosin-b.html
研究领域:Cell Cycle/DNA Damage
作用靶点:DNA/RNA Synthesis
来源:植物 | 菊科 | 大黄橐吾 | 植物 | 唇形科
In Vitro: Rabdosin B (200 μM; 3-12 h) induces cell cycle retardation of the G2 phase and S phase in root meristematic cells. Rabdosin B shows a time- and dose-dependent increase in DNA damage.
Rabdosin B shows a biphasic, dose-dependent effect on root growth and a strong inhibitory effect on root hair development in lettuce seedlings (Lactuca sativa L.). Lower concentrations of Rabdosin B (20-80 μM) significantly promots root growth, but its higher levels at 120-200 μM, by contrast, has inhibitory effects. Additionally, all tested concentrations (10-40 μM) inhibits root hair development of seedlings in a dose-dependent manner.
Rabdosin B has cytotoxic against human tumour HepG2, GLC-82 and HL-60 cell lines with IC50 values of 8.95 μM, 4.47 μM and 10.22 μM, respectively.
Rabdosin B (6 μM, 9 μM, 12 μM, 15 μM; 24-48 hours) induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner.
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