Rabdosin B | MedChemExpress (MCE)

Rabdosin B 产品活性：Rabdosin B，一种 ent-kaurene 二萜类化合物，具有抗癌作用。Rabdosin B 在细胞中诱导 DNA 损伤，并抑制幼苗生菜根毛的发育。 产品来源： https://www.medchemexpress.cn/rabdosin-b.html 研究领域：Cell Cycle/DNA Damage 作用靶点：DNA/RNA Synthesis 来源：植物 | 菊科 | 大黄橐吾 | 植物 | 唇形科 In Vitro: Rabdosin B (200 μM; 3-12 h) induces cell cycle retardation of the G2 phase and S phase in root meristematic cells. Rabdosin B shows a time- and dose-dependent increase in DNA damage. Rabdosin B shows a biphasic, dose-dependent effect on root growth and a strong inhibitory effect on root hair development in lettuce seedlings (Lactuca sativa L.). Lower concentrations of Rabdosin B (20-80 μM) significantly promots root growth, but its higher levels at 120-200 μM, by contrast, has inhibitory effects. Additionally, all tested concentrations (10-40 μM) inhibits root hair development of seedlings in a dose-dependent manner. Rabdosin B has cytotoxic against human tumour HepG2, GLC-82 and HL-60 cell lines with IC50 values of 8.95 μM, 4.47 μM and 10.22 μM, respectively. Rabdosin B (6 μM, 9 μM, 12 μM, 15 μM; 24-48 hours) induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner. 相关产品：Cycloheximide | Actinomycin D | Oxaliplatin | Gemcitabine | Bleomycin sulfate | Carboplatin | Mitomycin C | Cytarabine | 5-BrdU | Methotrexate | Streptozotocin | Anisomycin | Fludarabine | ART558 | Propidium Iodide | Thymidine | Hydroxyurea | Daunorubicin hydrochloride | Remdesivir | Capecitabine | Brequinar | Urolithin A | Folic acid | CX-5461 | α-Amanitin | Branaplam | Epirubicin hydrochloride | Plicamycin 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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