耗材描述
Berbamine
产品活性:Berbamine是一种从中药黄柏中提取的天然化合物,具有抗肿瘤,免疫调节和心血管作用。 Berbamine是一种钙通道阻滞剂。
产品来源: https://www.medchemexpress.cn/Berbamine.html
研究领域:NF-κB | Autophagy
作用靶点:NF-κB | Autophagy
来源:植物 | 芸香科 | 黄柏
结构分类:生物碱 | 异喹啉类生物碱 | 酚类 | 单酚类 | 结构分类
In Vitro: Berbamine (8.17 μg/mL, 24 h) inhibits the growth of KM3 cells with an inhibition of 50%.Berbamine (185.20 μg/mL, 48 h) induces apoptosis of normal hematopoietic cells with an inhibition of 50%.Berbamine (8 μg/mL, 24 h) inhibits the growth of KM3 cells with a percentage of apoptotic cells is 14.32%.Berbamine (8 μg/mL, 24 h) inhibits p65 nuclear translocation and expression of IKKα.
In Vivo: Berbamine (100 mg/kg, oral ) suppresses the growth of Huh7 xenografted tumors over time and leads to a tumor reduction of 70% based on the tumor weight.
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