Tenuifolin 产品活性：Tenuifolin 是能够从远志中分离出的三萜，具有口服活性和神经保护作用。Tenuifolin 可通过抑制 β-secretase 减少 Aβ 蛋白分泌，并抑制 Aβ25-35 诱导的细胞凋亡、以及 caspase-3 和 caspase-9 的激活。Tenuifolin 还能够降低 AChE 活性，同时增加去甲肾上腺素和多巴胺等神经递质的水平，来改善衰老小鼠的学习和记忆能力。Tenuifolin 有潜力用于阿尔茨海默氏病 (AD) 的研究。 产品来源： https://www.medchemexpress.cn/tenuifolin.html 研究领域：Neuronal Signaling 作用靶点：Beta-secretase | Cholinesterase (ChE) 来源：植物 | 远志科 | 远志 结构分类：萜类 | 三萜 | 结构分类 In Vitro: Tenuifolin (50 μM; 24 h) protects SH-SY5Y cells against Aβ25-35 (20 μM)-induced apoptosis, and decreased the mRNA level of caspase-3 and -9.Tenuifolin (50 μM, 100 μM; 24 h) inhibits Aβ25-35 (20 μM)-induced the loss of mitochondria-membrane potential in SH-SY5Y cells. In Vivo: Tenuifolin (20-80 mg/kg; po; single dose) induces beneficial effects on learning and memory, prevents loss and apoptosis of neurons in APP/PS1 mice. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Neuronal Signaling Compound Library | Natural Product Library | Glycoside Compound Library | Terpenoids Library | Orally Active Compound Library | Traditional Chinese Medicine Active Compound Library | Anti-Alzheimer's Disease Compound Library | Neuroprotective Compound Library | Neurodegenerative Disease-related Compound Library | Plant-Sourced Natural Product Library | Heterocyclic Compound Library | Protease Inhibitor Library | Membrane Protein-targeted Compound Library | Multi-Target Compound Library | Bioactive Compound Library Max | Dimethyl sulfoxide | Donepezil Hydrochloride | TMPyP4 tosylate | α-NETA | Galanthamine | Physostigmine salicylate | Scopoletin | Garcinol | Rivastigmine | Verubecestat | Se-Methylselenocysteine | (-)-Huperzine A | Protopine | Protriptyline hydrochloride | sn-Glycero-3-phosphocholine | Imperatorin | Acetylcholinesterase, Fly head | Hemicholinium 3 | Lanabecestat | Tacrine hydrochloride | Demethoxycurcumin | Linarin | Tacrine | Timosaponin AIII | Corynoline | Epiberberine chloride | LY2886721 | Pyridostigmine bromide | Sinapine 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。