耗材描述
Narciclasine
产品活性:Narciclasine是一种植物生长调节剂。 Narciclasine调节Rho/Rho 激酶/LIM 激酶/cofilin信号传导途径,大大增加GTP酶RhoA活性以及以RhoA依赖性方式诱导肌动蛋白应力纤维形成。
产品来源: https://www.medchemexpress.cn/Narciclasine.html
研究领域:Cell Cycle/DNA Damage | Stem Cell/Wnt | Cytoskeleton | TGF-beta/Smad
作用靶点:ROCK
来源:植物 | 石蒜科 | 水仙
结构分类:生物碱 | 异喹啉类生物碱 | 结构分类
In Vitro: Narciclasine activates Rho and stress fibers in glioblastoma multiforme cells. The mean IC50 of ~50 nM calculated on the 6 human glioblastoma multiforme (U373, Hs683, GL19, GL5, GL16, GL17), The mean IC50 value of 47 nM for Narciclasine across a panel of 60 cancer cell lines. Bioassay-guided fractionation of the A. belladonna extract resulted in the identification of lycorine as the bio-active compound. The IC50 measured for radicle growth inhibition is 0.1 μM for Narciclasine.
In Vivo: The i.v. regimen of Narciclasine at 1 mg/kg significantly (P=0.02) increases the survival of GL19 glioblastoma multiforme-bearing mice. Narciclasine when given orally at the same dose five times a week for 5 consecutive weeks also significantly increases animal survival in this model (P=0.008). Oral treatment with Narciclasine at 1 mg/kg significantly increases the survival (P=0.004) of Hs683 glioblastoma multiforme-bearing mice. Increasing the number of doses administered per week does not increase the survival of these Hs683 glioblastoma multiforme-bearing mice. Narciclasine appears to show similar increased survival in these models to temozolomide but at appreciable lower doses and following both oral and i.v. administration.
相关产品:Natural Product Library Plus | Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Stem Cell Signaling Compound Library | TGF-beta/Smad Compound Library | Natural Product Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Cytoskeleton Compound Library | Alkaloids Library | Anti-Colorectal Cancer Compound Library | Anti-Cancer Natural Product Library | Protein-protein Interaction Inhibitor Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Antihypertensive Compound Library | Membrane Protein-targeted Compound Library | Extracellular Vesicles (EVs) Compound Library | Bioactive Compound Library Max | Y-27632 | Chroman 1 | Fasudil Hydrochloride | Belumosudil | Thiazovivin | Afuresertib | GSK269962A | H-1152 dihydrochloride | GSK429286A | Ripasudil | Y-33075 | CCG-222740 | AT13148 | Pentanoic acid | ROCK inhibitor-2 | RKI-1447 | CMPD101 | GSK180736A | HA-100 | SAR407899 | LX7101 | Zelasudil | SR-3677 | CRT0066854 | BDP5290
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