Narciclasine | 水仙环素 | MedChemExpress (MCE)

Narciclasine 产品活性：Narciclasine是一种植物生长调节剂。 Narciclasine调节Rho/Rho 激酶/LIM 激酶/cofilin信号传导途径，大大增加GTP酶RhoA活性以及以RhoA依赖性方式诱导肌动蛋白应力纤维形成。 产品来源： https://www.medchemexpress.cn/Narciclasine.html 研究领域：Cell Cycle/DNA Damage | Stem Cell/Wnt | Cytoskeleton | TGF-beta/Smad 作用靶点：ROCK 来源：植物 | 石蒜科 | 水仙 结构分类：生物碱 | 异喹啉类生物碱 | 结构分类 In Vitro: Narciclasine activates Rho and stress fibers in glioblastoma multiforme cells. The mean IC50 of ~50 nM calculated on the 6 human glioblastoma multiforme (U373, Hs683, GL19, GL5, GL16, GL17), The mean IC50 value of 47 nM for Narciclasine across a panel of 60 cancer cell lines. Bioassay-guided fractionation of the A. belladonna extract resulted in the identification of lycorine as the bio-active compound. The IC50 measured for radicle growth inhibition is 0.1 μM for Narciclasine. In Vivo: The i.v. regimen of Narciclasine at 1 mg/kg significantly (P=0.02) increases the survival of GL19 glioblastoma multiforme-bearing mice. Narciclasine when given orally at the same dose five times a week for 5 consecutive weeks also significantly increases animal survival in this model (P=0.008). Oral treatment with Narciclasine at 1 mg/kg significantly increases the survival (P=0.004) of Hs683 glioblastoma multiforme-bearing mice. Increasing the number of doses administered per week does not increase the survival of these Hs683 glioblastoma multiforme-bearing mice. Narciclasine appears to show similar increased survival in these models to temozolomide but at appreciable lower doses and following both oral and i.v. administration. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Stem Cell Signaling Compound Library | TGF-beta/Smad Compound Library | Natural Product Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Cytoskeleton Compound Library | Alkaloids Library | Anti-Colorectal Cancer Compound Library | Anti-Cancer Natural Product Library | Protein-protein Interaction Inhibitor Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Antihypertensive Compound Library | Membrane Protein-targeted Compound Library | Extracellular Vesicles (EVs) Compound Library | Bioactive Compound Library Max | Y-27632 | Chroman 1 | Fasudil Hydrochloride | Belumosudil | Thiazovivin | Afuresertib | GSK269962A | H-1152 dihydrochloride | GSK429286A | Ripasudil | Y-33075 | CCG-222740 | AT13148 | Pentanoic acid | ROCK inhibitor-2 | RKI-1447 | CMPD101 | GSK180736A | HA-100 | SAR407899 | LX7101 | Zelasudil | SR-3677 | CRT0066854 | BDP5290 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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