耗材描述
EGCG-4″-sulfate
产品活性:EGCG-4″-sulfate 是绿茶中的一种主要多酚,可抑制细胞增殖并诱导细胞凋亡。 EGCG-4″-sulfate 可抑制谷氨酸脱氢酶 1/2 (GDH1/2, GLUD1/2) 的活性。EGCG-4″-sulfate 对结直肠癌、髓性白血病、甲状腺癌等多种癌症具有有效的抗癌、抗氧化和抗炎特性。
产品来源: https://www.medchemexpress.cn/egcg-4-sulfate.html
研究领域:Metabolic Enzyme/Protease | Apoptosis
作用靶点:Endogenous Metabolite | Apoptosis
结构分类:黄酮类 | 黄烷醇类 | 结构分类
In Vitro: EGCG-4″-sulfate (10-60 μM) inhibits the growth of FB-2 and WRO cells in a dose-dependent manner.
EGCG-4″-sulfate (10-60 μM, 0-24 h) reduces cyclin D1 and phosphorylation of AKT and ERK1/2, and increases p21 and p53 expression.
EGCG-4″-sulfate (10-60 μM, 12 h) reduces cell motility and migration.
EGCG-4″-sulfate (0-20 μM, 0-20 min approximately) inhibits GLUD1/2 and IDH1 activity in a concentration and time-dependent way (biochemical assays).
EGCG-4″-sulfate (0-35 μg/mL, 24-72 h) inhibits the proliferation of colorectal cancer cells (LoVo, SW480, HT-29, HCT-8 cells), increases cell apoptosis and blocks cells at the G0/G1 phase.
EGCG-4″-sulfate (30 μM, 3-24 h) suppresses the expression of COX-2 and mPGES-1 mRNAs, prostaglandin E2 production in LPS-induced osteoblasts.
In Vivo: EGCG-4″-sulfate (Intragastrical administration, 5-20 mg/kg, once daily for 14 days, orthotopic transplant model) decreases tumors growth.
EGCG-4″-sulfate (Injected into the mouse lower gingiva, a single dose of 0.5 mg/mouse, experimental periodontitis model) decreases inhibits the LPS-induced loss of bone mineral density (BMD).
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