耗材描述
NADH-IN-1
产品活性:NADH-IN-1 对 NADH: 泛醌氧化还原酶 (NADH:ubiquinone oxidoreductase) 具有抑制活性,IC50 为 27 μM。NADH-IN-1 在体外能有效刺激葡萄糖摄取。NADH-IN-1易被肝脏代谢。可用于糖尿病的研究。
产品来源: https://www.medchemexpress.cn/nadh-in-1.html
研究领域:Metabolic Enzyme/Protease
作用靶点:Endogenous Metabolite
结构分类:其他类 | 结构分类
In Vivo: NADH-IN-1 (1 μM) exhibits a short half-life and fast intrinsic clearance indicating that it is readily metabolised by the liver in vivo; shows no adverse effects on primary rat hepatocytes, and does not inhibit the hERG channel.
NADH-IN-1 (10 mg/kg; IV or PO; single dosage) produces no observable toxic effects at 10 mg/kg by IV or PO; exhibits a short half-life and high plasma clearance; exhibits high mouse and human serum protein binding, as well as moderate bioavailability.
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