BIO-1211 产品活性：BIO-1211 是高度选择性的、具有口服活性的 α4β1 (VLA-4) 抑制剂，其对 α4β1 和 α4β7 的 IC50 值分别为 4 nM 和 2 μM。 产品来源： https://www.medchemexpress.cn/bio-1211.html 研究领域：Cytoskeleton 作用靶点：Integrin In Vitro: BIO-1211 almostly exhibits no activity for α1β1, α5β1, α6β1, αLβ2 and αIIbβ3. In Vivo: BIO-1211 (5 and 10 mg/kg, orally, once every other day) results in reduced cytokines expression, leukocyte trafficking, and inhibition of inflammatory responses in EAE in a dose-independent manner. BIO-1211 exhibits a considerable depletion in the EAE clinical score, which correlated with decreased expression of TNF-α, IL-17, IFN-γ and pervade of CD11b+ and CD45+ cells into the cerebral cortex. 相关产品：Covalent Screening Library Plus | Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Clinical Compound Library | Drug Repurposing Compound Library | Covalent Screening Library | Cytoskeleton Compound Library | Orally Active Compound Library | Peptide Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | Extracellular Vesicles (EVs) Compound Library | Multi-Target Compound Library | Bioactive Compound Library Max | Cilengitide | Cyclo(-RGDfK) | Cucurbitacin B | GLPG0187 | E7820 | MK-0429 | CWHM-12 | Pyrintegrin | Lifitegrast | ATN-161 trifluoroacetate salt | Bexotegrast | Arg-Gly-Asp-Ser | Fibronectin | αvβ1 integrin-IN-1 TFA | Tirofiban | A-205804 | iRGD peptide | GPRP acetate | Carotegrast methyl | Eptifibatide | Vedolizumab | RGD peptide (GRGDNP) (TFA) | RGD | Natalizumab | Tetrac | Leukadherin-1 | BIO5192 | Cyclo(RGDyK) trifluoroacetate 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。