NPS-2143

面议

品牌：阿拉丁
厂商性质：生产商
产地类别：国产
产地：上海
货期：现货
服务地域：全国
规格：3
近期咨询：0

分子式 C24H25ClN2O2 分子量408.93 属性溶解性 DMSO 82 mg/mL Water <1 mg/mL Ethanol <1 mg/mL 存贮条件储存温度-20°C //decorateTable('pr

上海阿拉丁生化科技股份有限公司

上海阿拉丁生化科技股份有限公司

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配套的仪器设备？可以搭配的相关耗材试剂？

货号	CAS号	操作
N125903-25mg	284035-33-2	询底价
N125903-5mg	284035-33-2	询底价
N125903-100mg	284035-33-2	询底价

耗材描述

分子式 C₂₄H₂₅ClN₂O₂
分子量408.93

属性

溶解性	DMSO 82 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件	储存温度-20°C

描述

产品介绍	NPS-2143(SB 262470A)是选择性的Ca(2+)受体拮抗剂，IC50为43 nM。
生化机理	NPS 2143, even when tested at much higher concentrations (3 microM), did not affect the activity of a number of other G protein-coupled receptors, including those most structurally homologous to the Ca2+ receptor. NPS 2143 stimulated parathyroid hormone (PTH) secretion from bovine parathyroid cells (EC50 of 41 nM) over a range of extracellular Ca2+ concentrations and reversed the effects of the calcimimetic compound NPS R-467 on [Ca2+]i and on secretion of PTH [1]. The first reported calcilytic compound was NPS 2143, an orally active molecule which elicits rapid, 3- to 4-fold increases in circulating levels of PTH .
别名	NPS 2143; SB 262470A; NPS2143;2-氯-6-[(2R)-3-[[1,1-二甲基-2-(2-萘基)乙基]氨基]-2-羟基丙氧基]苯腈;NPS 2143; SB 262470A; NPS2143;2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile

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