N125903-5mgNPS-2143
面议
- 阿拉丁
- 生产商
- N125903-5mg
- 现货
- 全国
规格 |
---|
耗材描述
- 分子式 C24H25ClN2O2
- 分子量408.93
属性
溶解性 |
|
存贮条件 | 储存温度-20°C |
描述
产品介绍 | NPS-2143(SB 262470A)是选择性的Ca(2+)受体拮抗剂,IC50为43 nM。 |
生化机理 | NPS 2143, even when tested at much higher concentrations (3 microM), did not affect the activity of a number of other G protein-coupled receptors, including those most structurally homologous to the Ca2+ receptor. NPS 2143 stimulated parathyroid hormone (PTH) secretion from bovine parathyroid cells (EC50 of 41 nM) over a range of extracellular Ca2+ concentrations and reversed the effects of the calcimimetic compound NPS R-467 on [Ca2+]i and on secretion of PTH [1]. The first reported calcilytic compound was NPS 2143, an orally active molecule which elicits rapid, 3- to 4-fold increases in circulating levels of PTH . |
别名 | NPS 2143; SB 262470A; NPS2143;2-氯-6-[(2R)-3-[[1,1-二甲基-2-(2-萘基)乙基]氨基]-2-羟基丙氧基]苯腈;NPS 2143; SB 262470A; NPS2143;2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile |
猜你喜欢
感兴趣产品