Product Introduction
Bioactivity


英文名: Doxylamine succinate

描述: Doxylamine succinate (Decapryn) 是一种吡啶衍生物组胺 H1 拮抗剂，具有明显的镇静特性。它竞争性阻断组胺 H1 受体并限制典型的过敏和过敏反应，可防止组胺引起的皮肤和粘膜疼痛和瘙痒。

体外活性: 在B6C3F1小鼠体内,以Doxylamine琥珀酸盐形式,食物摄取7天或15天(饮食中含量0, 40, 375, 750, or 1500 ppm, 以游离碱Doxylamine形式)的方式考察了Doxylamine对微粒体酶活性和血清甲状腺激素水平的影响.结果发现在B6C3F1小鼠体内,Doxylamine是肝微粒体细胞色素P450?的巴比妥类诱导剂,且与Doxylamine提升了参与T4代谢的肝酶活性的假说相一致.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (257.43 mM)
H2O : 100 mg/mL (257.43 mM)


关键字: B6C3F1 mice | Low toxicity | Liver | inhibit | Subcutaneous infiltration | Doxylamine Succinate | Doxylamine succinate | Inhibitor | Histamine Receptor | Local analgesic | Doxylamine

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相关库: Drug Repurposing Compound Library | Approved Drug Library | Histamine & Melatonin Receptor-Targeted Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Neuronal Signaling Compound Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | GPCR Compound Library | Anti-Cancer Approved Drug Library