琥珀酸多西拉敏 T1115

Product Introduction
Bioactivity


英文名: Doxylamine succinate

描述: Doxylamine succinate (Decapryn) 是一种吡啶衍生物组胺 H1 拮抗剂，具有明显的镇静特性。它竞争性阻断组胺 H1 受体并限制典型的过敏和过敏反应，可防止组胺引起的皮肤和粘膜疼痛和瘙痒。

体外活性: 在B6C3F1小鼠体内,以Doxylamine琥珀酸盐形式,食物摄取7天或15天(饮食中含量0, 40, 375, 750, or 1500 ppm, 以游离碱Doxylamine形式)的方式考察了Doxylamine对微粒体酶活性和血清甲状腺激素水平的影响.结果发现在B6C3F1小鼠体内,Doxylamine是肝微粒体细胞色素P450?的巴比妥类诱导剂,且与Doxylamine提升了参与T4代谢的肝酶活性的假说相一致.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (257.43 mM)
H2O : 100 mg/mL (257.43 mM)


关键字: B6C3F1 mice | Low toxicity | Liver | inhibit | Subcutaneous infiltration | Doxylamine Succinate | Doxylamine succinate | Inhibitor | Histamine Receptor | Local analgesic | Doxylamine

相关产品: Metiamide | FRG8701 | Nortriptyline hydrochloride | Daurinoline | Mirtazapine | JNJ-5207852 dihydrochloride | Meclizine dihydrochloride | Bavisant | Imetit dihydrobromide | Diphenhydramine

相关库: Drug Repurposing Compound Library | Approved Drug Library | Histamine & Melatonin Receptor-Targeted Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Neuronal Signaling Compound Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | GPCR Compound Library | Anti-Cancer Approved Drug Library

琥珀酸多西拉敏 T1115信息由TargetMol中国为您提供，如您想了解更多关于琥珀酸多西拉敏 T1115报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途