化合物 T11185 T11185
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Product IntroductionBioactivity英文名: EML741描述: EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT
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Product Introduction
Bioactivity
英文名: EML741
描述: EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barrier penetrated. EML741 is a histone lysine methyltransferase G9a/GLP inhibitor, with an IC50 of 23 nM, Kd of 1.13 μM for G9a.
体外活性: EML741 ?shows a similar high inhibition potency against G9a (97%, 98% inhibition at 10 μM and 25 μM, respectively) and GLP (95%, 98% inhibition at 10 μM and 25 μM, respectively).
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: EML741 | EML 741 | EML-741
相关产品: BAY-598 | WDR5-47 | MS023 | SGC707 | SGC-iMLLT | Valemetostat tosylate | Cyproheptadine hydrochloride sesquihydrate | PF-06726304 | CARM1 degrader-2 | MS37452
Bioactivity
英文名: EML741
描述: EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barrier penetrated. EML741 is a histone lysine methyltransferase G9a/GLP inhibitor, with an IC50 of 23 nM, Kd of 1.13 μM for G9a.
体外活性: EML741 ?shows a similar high inhibition potency against G9a (97%, 98% inhibition at 10 μM and 25 μM, respectively) and GLP (95%, 98% inhibition at 10 μM and 25 μM, respectively).
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: EML741 | EML 741 | EML-741
相关产品: BAY-598 | WDR5-47 | MS023 | SGC707 | SGC-iMLLT | Valemetostat tosylate | Cyproheptadine hydrochloride sesquihydrate | PF-06726304 | CARM1 degrader-2 | MS37452
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