化合物 T11185 T11185

Product Introduction
Bioactivity


英文名: EML741

描述: EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barrier penetrated. EML741 is a histone lysine methyltransferase G9a/GLP inhibitor, with an IC50 of 23 nM, Kd of 1.13 μM for G9a.

体外活性: EML741 ?shows a similar high inhibition potency against G9a (97%, 98% inhibition at 10 μM and 25 μM, respectively) and GLP (95%, 98% inhibition at 10 μM and 25 μM, respectively).

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: EML741 | EML 741 | EML-741

相关产品: BAY-598 | WDR5-47 | MS023 | SGC707 | SGC-iMLLT | Valemetostat tosylate | Cyproheptadine hydrochloride sesquihydrate | PF-06726304 | CARM1 degrader-2 | MS37452

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途