Product Introduction
Bioactivity


英文名: NMS-P715

描述: NMS-P715 是一种 ATP 竞争性MPS1选择性抑制剂，IC50值为 182 nM。

体外活性: NMS-P715 (1 μM) 抑制HCT116细胞的增殖，并在过表达YFP-α-tubulin的U2OS细胞中加速有丝分裂。NMS-P715（0.5，1 μM）影响有丝分裂检查点复合体（MCC）的稳定性及cdc20的泛素化[1]。

体内活性: NMS-P715（90 mg/kg，口服）在A2780卵巢癌异种移植模型中耐受性良好，未引起体重减轻或其他明显毒性反应[1]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 2 mg/mL (2.96 mM)


关键字: NMS-P 715 | Monopolar spindle 1 | Mps1 | NMS P715 | NMS-P-715 | inhibit | NMSP715 | Inhibitor | NMS-P715

相关产品: PF-4800567 | Casein kinase 1δ-IN-6 | Silmitasertib | TBCA | A-443654 | TBB | Casein kinase 1δ-IN-7 | Silmitasertib sodium salt | TA-01 | WAY-297174

相关库: HIF-1 Signaling Pathway Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Lung Cancer Compound Library | Inhibitor Library | Kinase Inhibitor Library | Anti-Cancer Active Compound Library | Metabolism Compound Library | Preclinical Compound Library | MAPK Inhibitor Library | Bioactive Compound Library