化合物 CHDI-390576 T14947
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Product IntroductionBioactivity英文名: CHDI-390576描述: CHDI-390576 is a CNS penetrant class IIa HDAC inhibitor (IC50s: 54 nM,
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Product Introduction
Bioactivity
英文名: CHDI-390576
描述: CHDI-390576 is a CNS penetrant class IIa HDAC inhibitor (IC50s: 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9). It shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform.
体外活性: CHDI-390576 inhibits class I HDACs (1, 3, 8) and class IIb HDAC6 isoforms (IC50s: 39.7μM, 25.8 μM, 9.1 μM, 6.2 μM). To the catalytic domain of immobilized HDAC4, the Kd of CHDI-390576 is 80 nM.
存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: CHDI-390576 | CHDI390576 | CHDI 390576
相关产品: BRD3308 | JPS016 TFA | HDAC-IN-60 | ACY-738 | FT895 | Parthenolide | SGC-UBD253 | Tenovin-6 Hydrochloride | BRD4097 | WT-161
Bioactivity
英文名: CHDI-390576
描述: CHDI-390576 is a CNS penetrant class IIa HDAC inhibitor (IC50s: 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9). It shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform.
体外活性: CHDI-390576 inhibits class I HDACs (1, 3, 8) and class IIb HDAC6 isoforms (IC50s: 39.7μM, 25.8 μM, 9.1 μM, 6.2 μM). To the catalytic domain of immobilized HDAC4, the Kd of CHDI-390576 is 80 nM.
存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: CHDI-390576 | CHDI390576 | CHDI 390576
相关产品: BRD3308 | JPS016 TFA | HDAC-IN-60 | ACY-738 | FT895 | Parthenolide | SGC-UBD253 | Tenovin-6 Hydrochloride | BRD4097 | WT-161
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