化合物 CHDI-390576 T14947

Product Introduction
Bioactivity


英文名: CHDI-390576

描述: CHDI-390576 is a CNS penetrant class IIa HDAC inhibitor (IC50s: 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9). It shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform.

体外活性: CHDI-390576 inhibits class I HDACs (1, 3, 8) and class IIb HDAC6 isoforms (IC50s: 39.7μM, 25.8 μM, 9.1 μM, 6.2 μM). To the catalytic domain of immobilized HDAC4, the Kd of CHDI-390576 is 80 nM.

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: CHDI-390576 | CHDI390576 | CHDI 390576

相关产品: BRD3308 | JPS016 TFA | HDAC-IN-60 | ACY-738 | FT895 | Parthenolide | SGC-UBD253 | Tenovin-6 Hydrochloride | BRD4097 | WT-161

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途