Product Introduction
Bioactivity


英文名: ML-9

描述: ML-9 是 Akt 激酶的一种选择性强效抑制剂，可抑制肌球蛋白轻链激酶 (MLCK) 和基质相互作用分子1(STIM1) 活性。它通过刺激自噬小体的形成并抑制其降解来诱导自噬。它抑制 MLCK，PKA 和 PKC 活性，Ki 值分别为 4、32 和 54 μM。

体外活性: ML9 (50?μM; 1-4?hours) obviously enhances cleaved caspase-3 levels, reduced STIM1 protein levels by about 42%. ML9 (0-100?μM; 0-24?hours) has no reduction in cardiomyocyte viability, 50-100?μM obviously causes cell death [2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 25 mg/mL (69.2 mM)


关键字: viability | STIM1 | Inhibitor | ML9 | MLCK | ML-9 | caspase | Myosin | inhibit | ML 9 | cardiomyocyte

相关产品: Danicamtiv | JB062 | HA-100 | para-Nitroblebbistatin | Mavacamten | BTS | Phenamacril | ML-7 hydrochloride | Blebbistatin | Myosin V-IN-1

相关库: PI3K-AKT-mTOR Compound Library | HIF-1 Signaling Pathway Compound Library | Anti-Liver Cancer Compound Library | Anti-Cancer Compound Library | Angiogenesis related Compound Library | Neural Regeneration Compound Library | Anti-Ovarian Cancer Compound Library | Kinase Inhibitor Library | Inhibitor Library | Anti-Colorectal Cancer Compound Library