ML-9盐酸盐 T16104

Product Introduction
Bioactivity


英文名: ML-9

描述: ML-9 是 Akt 激酶的一种选择性强效抑制剂，可抑制肌球蛋白轻链激酶 (MLCK) 和基质相互作用分子1(STIM1) 活性。它通过刺激自噬小体的形成并抑制其降解来诱导自噬。它抑制 MLCK，PKA 和 PKC 活性，Ki 值分别为 4、32 和 54 μM。

体外活性: ML9 (50?μM; 1-4?hours) obviously enhances cleaved caspase-3 levels, reduced STIM1 protein levels by about 42%. ML9 (0-100?μM; 0-24?hours) has no reduction in cardiomyocyte viability, 50-100?μM obviously causes cell death [2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 25 mg/mL (69.2 mM)


关键字: viability | STIM1 | Inhibitor | ML9 | MLCK | ML-9 | caspase | Myosin | inhibit | ML 9 | cardiomyocyte

相关产品: Danicamtiv | JB062 | HA-100 | para-Nitroblebbistatin | Mavacamten | BTS | Phenamacril | ML-7 hydrochloride | Blebbistatin | Myosin V-IN-1

相关库: PI3K-AKT-mTOR Compound Library | HIF-1 Signaling Pathway Compound Library | Anti-Liver Cancer Compound Library | Anti-Cancer Compound Library | Angiogenesis related Compound Library | Neural Regeneration Compound Library | Anti-Ovarian Cancer Compound Library | Kinase Inhibitor Library | Inhibitor Library | Anti-Colorectal Cancer Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途