Product Introduction
Bioactivity


英文名: PI-828

描述: PI-828 是磷脂酰肌醇3-激酶(PI3K)抑制剂，广泛用于研究 PI3K 的生理功能，也可促进干细胞向中胚层分化。

体外活性: PI-828 (0.78-3.12 µM; 48 hours) reduces caspase 3 activation. However, higher concentrations of PI-828 (6.25-12.5 μM) alone causes apoptosis[2].The sensitivity to PI-828 is a key feature of PI3K-C2β that shows a different sensitivity to this inhibitor compared to class I PI3Ks. Of note, 1 μM PI-828 has no effect on the activity of PI3K-C2β, while it significantly inhibits class I PI3Ks. In particular, a concentration of 10 μM PI-828 completely blocks class I PI3Ks, whereas it has only a partial inhibitory effect on PI3K-C2β[4]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 11.2 mg/mL (34.9 mM)


关键字: PI 828 | LY-294002, 4gamma-NH2 | PI828 | PI-828 | LY294002

相关产品: CKI-7 | CK1-IN-2 | Ac-VDVAD-CHO | Casein kinase 1δ-IN-6 | TBCA | TBB | Ellagic acid | Ellagic acid (hydrate) | TA-01 | Casein kinase 1δ-IN-1

相关库: Antioxidant Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | Anti-Obesity Compound Library | Metabolism Compound Library | Bioactive Compound Library