化合物 T16900 T16900
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Product IntroductionBioactivity英文名: SMER18描述: SMER18 is a small molecule enhancer of rapamycin which acts as an mTOR-inde
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Product Introduction
Bioactivity
英文名: SMER18
描述: SMER18 is a small molecule enhancer of rapamycin which acts as an mTOR-independent autophagy inducer.
体外活性: SMER18 acts either independently or downstream of the target of Rapamycin, attenuates mutant huntingtin-fragment toxicity in Huntington's disease cell and Drosophila melanogaster models. mTOR SMER18 induces autophagy independently of Rapamycin in mammalian cells, enhancing the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein, which are associated with Huntington's disease and familial Parkinson's disease, respectively.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: SMER18 | SMER-18 | SMER 18
Bioactivity
英文名: SMER18
描述: SMER18 is a small molecule enhancer of rapamycin which acts as an mTOR-independent autophagy inducer.
体外活性: SMER18 acts either independently or downstream of the target of Rapamycin, attenuates mutant huntingtin-fragment toxicity in Huntington's disease cell and Drosophila melanogaster models. mTOR SMER18 induces autophagy independently of Rapamycin in mammalian cells, enhancing the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein, which are associated with Huntington's disease and familial Parkinson's disease, respectively.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: SMER18 | SMER-18 | SMER 18
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