孕二烯二酮 T17280
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Product IntroductionBioactivity英文名: (Z)-Guggulsterone描述: (Z)-Guggulsterone 是印度阿育吠陀药用植物Commiphora mukul 的成分，可通过引起细胞凋亡来抑制人前
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Product Introduction
Bioactivity
英文名: (Z)-Guggulsterone
描述: (Z)-Guggulsterone 是印度阿育吠陀药用植物Commiphora mukul 的成分，可通过引起细胞凋亡来抑制人前列腺癌细胞的生长，还可通过抑制VEGF-VEGF-R2-Akt 信号传导轴来抑制血管生成。
体外活性: In HUVEC, Z-guggulsterone (10, 20 μM; 24 or 48 hours) induces a reduction in the level of VEGF-R2 protein [1].
体内活性: In tumor volume and wet tumor weight, Z-guggulsterone (p.o.; 1 mg; 5 times/week) causes a statistically significant reduction [1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 10 mg/mL (32.01 mM)
关键字: inhibit | VEGFR | Protein kinase B | PKB | Inhibitor | Guggulsterone | (Z)-Guggulsterone | (Z) Guggulsterone | Vascular endothelial growth factor receptor | Akt | (Z)Guggulsterone | Apoptosis
相关产品: CP 461 | Bufotalin | Scoulerine | Lawsone methyl ether | Polyphyllin II | ranaconitine | Furanodiene | Vesatolimod | PRMT6-IN-3 | Fosbretabulin Disodium
相关库: Antioxidant Compound Library | PI3K-AKT-mTOR Compound Library | Glutamine Metabolism Compound Library | Selected Plant-Sourced Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Kinase Inhibitor Library | Anti-Cancer Active Compound Library | Tyrosine Kinase Inhibitor Library | Apoptosis Compound Library
Bioactivity
英文名: (Z)-Guggulsterone
描述: (Z)-Guggulsterone 是印度阿育吠陀药用植物Commiphora mukul 的成分，可通过引起细胞凋亡来抑制人前列腺癌细胞的生长，还可通过抑制VEGF-VEGF-R2-Akt 信号传导轴来抑制血管生成。
体外活性: In HUVEC, Z-guggulsterone (10, 20 μM; 24 or 48 hours) induces a reduction in the level of VEGF-R2 protein [1].
体内活性: In tumor volume and wet tumor weight, Z-guggulsterone (p.o.; 1 mg; 5 times/week) causes a statistically significant reduction [1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 10 mg/mL (32.01 mM)
关键字: inhibit | VEGFR | Protein kinase B | PKB | Inhibitor | Guggulsterone | (Z)-Guggulsterone | (Z) Guggulsterone | Vascular endothelial growth factor receptor | Akt | (Z)Guggulsterone | Apoptosis
相关产品: CP 461 | Bufotalin | Scoulerine | Lawsone methyl ether | Polyphyllin II | ranaconitine | Furanodiene | Vesatolimod | PRMT6-IN-3 | Fosbretabulin Disodium
相关库: Antioxidant Compound Library | PI3K-AKT-mTOR Compound Library | Glutamine Metabolism Compound Library | Selected Plant-Sourced Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Kinase Inhibitor Library | Anti-Cancer Active Compound Library | Tyrosine Kinase Inhibitor Library | Apoptosis Compound Library
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