Product Introduction
Bioactivity


英文名: Zardaverine

描述: Zardaverine (BY 290) 是一种可口服且具有选择性和有效性的 PDE3/4 抑制剂 ，具有支气管扩张活性和抗肝癌活性。Zardaverine 在血小板中的作用是通过PDE III同工酶介导，可用于研究急性肾衰竭呵呵慢性气流阻塞。

体外活性: Zardaverine selectively inhibits the growth of human hepatocellular carcinoma (HCC) cells in vitro when administered at concentrations ranging from 0 to 30 µM for 72 hours[3].Selective antitumor activity of Zardaverine is observed, closely related to the regulation of cell cycle-associated proteins, but independent of PDE3/4 inhibition[3].At a concentration of 0.1 µM for 24 hours, Zardaverine selectively induces G0/G1-phase arrest and dysregulates cell cycle-associated proteins in HCC cells[3].Zardaverine induces apoptosis in a time- and concentration-dependent manner in Bel-7402 and SMMC-7721 cells. The concentrations used include 0.01, 0.03, 0.1, 0.3, and 1 µM over 48 hours, as well as 0.3 and 1 µM over 24, 36, 48, 60, and 72 hours[3].

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 20 mg/mL (74.57 mM)


关键字: Zardaverine

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