扎达维林 T17284

Product Introduction
Bioactivity


英文名: Zardaverine

描述: Zardaverine (BY 290) 是一种可口服且具有选择性和有效性的 PDE3/4 抑制剂 ，具有支气管扩张活性和抗肝癌活性。Zardaverine 在血小板中的作用是通过PDE III同工酶介导，可用于研究急性肾衰竭呵呵慢性气流阻塞。

体外活性: Zardaverine selectively inhibits the growth of human hepatocellular carcinoma (HCC) cells in vitro when administered at concentrations ranging from 0 to 30 µM for 72 hours[3].Selective antitumor activity of Zardaverine is observed, closely related to the regulation of cell cycle-associated proteins, but independent of PDE3/4 inhibition[3].At a concentration of 0.1 µM for 24 hours, Zardaverine selectively induces G0/G1-phase arrest and dysregulates cell cycle-associated proteins in HCC cells[3].Zardaverine induces apoptosis in a time- and concentration-dependent manner in Bel-7402 and SMMC-7721 cells. The concentrations used include 0.01, 0.03, 0.1, 0.3, and 1 µM over 48 hours, as well as 0.3 and 1 µM over 24, 36, 48, 60, and 72 hours[3].

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 20 mg/mL (74.57 mM)


关键字: Zardaverine

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途