Product Introduction
Bioactivity


英文名: AZ31

描述: AZ31 是一种 ATM 抑制剂，具有有效性、高选择性、和口服活性。AZ31对 ATM 酶、细胞内 ATM 具有抑制作用，IC50 值 分别为<1.2 nM 和 46 nM。AZ31 表现出优异的 ATR 选择性 、PIKK 家族选择性和泛激酶选择性。AZ31 是一种强效的体外放射增敏剂，可用于研究癌症。

体外活性: AZ31 (0.3-3 μM ; 1 h) modulates the phosphorylation of a range of ATM targets.[2] AZ31 (10 μM ; 1 h) influences the stabilization of p53 in H2228 lung cancer cells post-radiation.[2]

体内活性: AZ31 (50-100 mg/kg ; p.o. twice daily) exhibits limited penetration into the brain.[2]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 25 mg/mL (59.45 mM)


关键字: AZ31

相关产品: CGK733 | Schisandrin B | AZ20 | A011 | ATR-IN-29 | ATR-IN-24 | NU 7026 | VE-821 | ATR-IN-21 | M3541

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | Anti-Obesity Compound Library | Highly Selective Inhibitor Library | Anti-Cancer Active Compound Library | DNA Damage & Repair Compound Library | Bioactive Compound Library