Product Introduction
Bioactivity


英文名: Dehydrocrenatidine

描述: Dehydrocrenatidine (Kumujian G) 是 JAK 的抑制剂，可诱导细胞凋亡。

体外活性: In DU145 and MDA-MB-468 cells, Dehydrocrenatidine inhibits cell survival and induces cell apoptosis in a JAK-STAT3-dependent manner. Dehydrocrenatidine reduces the STAT3 phosphorylation stimulated by IL-6, IFN-α, and IFN-γ[1]. Dehydrocrenatidine reduces tetrodotoxin-resistant and sensitive voltage-gated sodium channel currents with IC50 values of 12.36 µM and 4.87 µM, respectively[2].

体内活性: Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain[2].

存储条件: store at low temperature,keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : Soluble


关键字: Dehydrocrenatidine

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