去氢苦木碱 T19934

Product Introduction
Bioactivity


英文名: Dehydrocrenatidine

描述: Dehydrocrenatidine (Kumujian G) 是 JAK 的抑制剂，可诱导细胞凋亡。

体外活性: In DU145 and MDA-MB-468 cells, Dehydrocrenatidine inhibits cell survival and induces cell apoptosis in a JAK-STAT3-dependent manner. Dehydrocrenatidine reduces the STAT3 phosphorylation stimulated by IL-6, IFN-α, and IFN-γ[1]. Dehydrocrenatidine reduces tetrodotoxin-resistant and sensitive voltage-gated sodium channel currents with IC50 values of 12.36 µM and 4.87 µM, respectively[2].

体内活性: Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain[2].

存储条件: store at low temperature,keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : Soluble


关键字: Dehydrocrenatidine

相关产品: Indibulin | Barasertib | ML141 | BiP inducer X | Alexidine dihydrochloride | PARP-2-IN-3 | CP-724714 | Quercetin | PATULIN | PAC-1

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途