化合物BMS 453 T21714
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Product IntroductionBioactivity英文名: BMS453描述: BMS453 (BMS-189453) 是一种合成类维生素 A，是一种 RARβ激动剂，也是一种 RARα/RARγ拮抗剂。它主要通过诱导活性 TGF
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Product Introduction
Bioactivity
英文名: BMS453
描述: BMS453 (BMS-189453) 是一种合成类维生素 A，是一种 RARβ激动剂，也是一种 RARα/RARγ拮抗剂。它主要通过诱导活性 TGFβ 来抑制乳腺细胞生长。
体外活性: BMS453 (1 μM; 11 hours; 184 and HMEC cells) treatment inhibits the proliferation of normal breast cell growth without significantly inducing apoptosis[2].The RARβ-selective agonist (BMS453), but not RARα- or RARγ-selective agonists (BMS753 and BMS961, respectively), significantly reduced the T47D breast cancer cell migration to levels comparable to inhibition by RA, indicating that RARβ is involved in RA-inhibited cell migration[3].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 45 mg/mL (118.27 mM)
关键字: Inhibitor | retinoid | BMS-453 | RAR/RXR | BMS453 | inhibit | BMS189453 | TGFβ | breast | RARβ | RARγ | Retinoid X receptors | arrest | cell | RARα | BMS 189453 | Retinoic acid receptors
相关产品: CD2665 | Tarenflurbil | palovarotene | PA452 | Magnolol | CD 1530 | Peretinoin | Isotretinoin | MSU-42011 | WYC-209
相关库: Neuronal Differentiation Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Nuclear Receptor Compound Library | Bioactive Compound Library
Bioactivity
英文名: BMS453
描述: BMS453 (BMS-189453) 是一种合成类维生素 A，是一种 RARβ激动剂，也是一种 RARα/RARγ拮抗剂。它主要通过诱导活性 TGFβ 来抑制乳腺细胞生长。
体外活性: BMS453 (1 μM; 11 hours; 184 and HMEC cells) treatment inhibits the proliferation of normal breast cell growth without significantly inducing apoptosis[2].The RARβ-selective agonist (BMS453), but not RARα- or RARγ-selective agonists (BMS753 and BMS961, respectively), significantly reduced the T47D breast cancer cell migration to levels comparable to inhibition by RA, indicating that RARβ is involved in RA-inhibited cell migration[3].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 45 mg/mL (118.27 mM)
关键字: Inhibitor | retinoid | BMS-453 | RAR/RXR | BMS453 | inhibit | BMS189453 | TGFβ | breast | RARβ | RARγ | Retinoid X receptors | arrest | cell | RARα | BMS 189453 | Retinoic acid receptors
相关产品: CD2665 | Tarenflurbil | palovarotene | PA452 | Magnolol | CD 1530 | Peretinoin | Isotretinoin | MSU-42011 | WYC-209
相关库: Neuronal Differentiation Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Nuclear Receptor Compound Library | Bioactive Compound Library
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