Product IntroductionBioactivity英文名:
S-Methylisothiourea sulfate描述: S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) 是一种选择性 iNOS 抑制剂,在感染性休克的啮齿动物模型中发挥有益作用。
动物实验: S-Methylisothiourea sulfate (Male Wistar rats (260-320 g); 0.01 mg/kg, 0.1 mg/kg, 1 mg/kg, 3 mg/kg; Intravenous injection) caused a prompt restoration of the blood pressure to pre-LPS levels at 3 mg/kg dose in LPS (10 mg/kg, i.v.)-treated rats and also inhibited iNOS activity measured in homogenates of lung[1].
体外活性: S-Methylisothiourea sulfate is a competitive inhibitor of iNOS activity at the L-arginine site. The effect of S-Methylisothiourea sulfate on iNOS activity can be reversed by excess L-arginine in a concentration-dependent manner. S-Methylisothiourea sulfate (up to 1 mM) does not inhibit the activity of xanthine oxidase, diaphorase, lactate dehydrogenase, monoamine oxidase, catalase, cytochrome P450, or superoxide dismutase. S-Methylisothiourea sulfate prevents the NO-mediated cytotoxic effect of LPS in cultured macrophages. S-Methylisothiourea sulfate (100 nM-100 μM) exhibits inhibitory effects on LPS (ug/mL)-induced nitrite production in J774.2 macrophages and rat aortic vascular smooth muscle cells[1].
体内活性: S-Methylisothiourea sulfate dose-dependently reverses (0.01-3 mg/kg) the hypotension and the vascular hyporeactivity to vasoconstrictor agents caused by endotoxin [bacterial lipopolysaccharide (LPS), 10 mg/kg, i.v.] in anesthetized rats. Moreover, therapeutic administration of S-Methylisothiourea sulfate (5 mg/kg, i.p., given 2 hr after LPS, 10 mg/kg, i.p.) attenuates the rises in plasma alanine and aspartate aminotransferases, bilirubin, and creatinine and also prevents hypocalcaemia when measured 6 hr after administration of LPS. S-Methylisothiourea sulfate (1 mg/kg, i.p.) improves 24-hr survival of mice treated with a high dose of LPS (60 mg/kg, i.p.)[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: H2O : 60 mg/mL (431.09 mM)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
关键字:
HSV |
septic |
S-Methylisothiourea |
blood |
NOS |
Methylisothiourea Sulfate |
S-Methylisothiourea Sulfate |
shock |
iNOS |
Nitric oxide synthases |
SMethylisothiourea sulfate |
Inhibitor |
Herpes simplex virus |
inhibit |
NO Synthase |
S Methylisothiourea sulfate |
hypotension |
pressure |
circulatory相关产品:
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Dunnianol |
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Catalposide |
3,4-DAA |
Regaloside B |
Triptoquinone A |
Goshonoside F5 |
GW274150 phosphate |
Zedoarondiol相关库:
Anti-Aging Compound Library |
Bioactive Compounds Library Max |
Inhibitor Library |
Anti-Viral Compound Library |
NO PAINS Compound Library |
Anti-Infection Compound Library |
Bioactive Compound Library