S-甲基异硫脲半硫酸盐 T22419

Product Introduction
Bioactivity


英文名: S-Methylisothiourea sulfate

描述: S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) 是一种选择性 iNOS 抑制剂，在感染性休克的啮齿动物模型中发挥有益作用。

动物实验: S-Methylisothiourea sulfate (Male Wistar rats (260-320 g); 0.01 mg/kg, 0.1 mg/kg, 1 mg/kg, 3 mg/kg; Intravenous injection) caused a prompt restoration of the blood pressure to pre-LPS levels at 3 mg/kg dose in LPS (10 mg/kg, i.v.)-treated rats and also inhibited iNOS activity measured in homogenates of lung[1].

体外活性: S-Methylisothiourea sulfate is a competitive inhibitor of iNOS activity at the L-arginine site. The effect of S-Methylisothiourea sulfate on iNOS activity can be reversed by excess L-arginine in a concentration-dependent manner. S-Methylisothiourea sulfate (up to 1 mM) does not inhibit the activity of xanthine oxidase, diaphorase, lactate dehydrogenase, monoamine oxidase, catalase, cytochrome P450, or superoxide dismutase. S-Methylisothiourea sulfate prevents the NO-mediated cytotoxic effect of LPS in cultured macrophages. S-Methylisothiourea sulfate (100 nM-100 μM) exhibits inhibitory effects on LPS (ug/mL)-induced nitrite production in J774.2 macrophages and rat aortic vascular smooth muscle cells[1].

体内活性: S-Methylisothiourea sulfate dose-dependently reverses (0.01-3 mg/kg) the hypotension and the vascular hyporeactivity to vasoconstrictor agents caused by endotoxin [bacterial lipopolysaccharide (LPS), 10 mg/kg, i.v.] in anesthetized rats. Moreover, therapeutic administration of S-Methylisothiourea sulfate (5 mg/kg, i.p., given 2 hr after LPS, 10 mg/kg, i.p.) attenuates the rises in plasma alanine and aspartate aminotransferases, bilirubin, and creatinine and also prevents hypocalcaemia when measured 6 hr after administration of LPS. S-Methylisothiourea sulfate (1 mg/kg, i.p.) improves 24-hr survival of mice treated with a high dose of LPS (60 mg/kg, i.p.)[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 60 mg/mL (431.09 mM)
DMSO : < 1 mg/mL (insoluble or slightly soluble)


关键字: HSV | septic | S-Methylisothiourea | blood | NOS | Methylisothiourea Sulfate | S-Methylisothiourea Sulfate | shock | iNOS | Nitric oxide synthases | SMethylisothiourea sulfate | Inhibitor | Herpes simplex virus | inhibit | NO Synthase | S Methylisothiourea sulfate | hypotension | pressure | circulatory

相关产品: Kazinol U | Dunnianol | Cnidicin | Catalposide | 3,4-DAA | Regaloside B | Triptoquinone A | Goshonoside F5 | GW274150 phosphate | Zedoarondiol

相关库: Anti-Aging Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Viral Compound Library | NO PAINS Compound Library | Anti-Infection Compound Library | Bioactive Compound Library

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