化合物L-168049 T22893
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Product IntroductionBioactivity英文名: L-168049描述: L-168049 是一种选择性和非竞争性人胰高血糖素受体拮抗剂，对人、鼠和犬的 IC50 分别为 3.7 nM、63 nM 和 60 nM。体外活
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Product Introduction
Bioactivity
英文名: L-168049
描述: L-168049 是一种选择性和非竞争性人胰高血糖素受体拮抗剂，对人、鼠和犬的 IC50 分别为 3.7 nM、63 nM 和 60 nM。
体外活性: In Chinese hamster ovary cells expressing the human glucagon receptor, L-168049 increases the apparent EC50 of glucagon-stimulated adenylate cyclase and decreases maximal glucagon stimulation with a Kb of 25 nM[1]. L-168049 blocks glucagon-stimulated cAMP formation in mouse liver membrane and inhibits glucagon (100 pM)-stimulated cAMP synthesis in CHO cells expressing the human glucagon receptor with IC50 of 41 nM [3].
体内活性: 在L-G6pc-/-小鼠的肝脏中，L-168049（每千克体重50毫克；经口给药）在6小时内将Pck1 mRNA表达量减少了一半。L-168049阻止了肾脏和肠道中G6pc表达量的增加[2]。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Ethanol : 3.4mM
DMSO : insoluble
关键字: L-168049 | L168049 | L 168049
相关产品: Lixisenatide acetate (320367-13-3 free base) | GLP-1(7-36), amide | Adomeglivant | Oxyntomodulin acetate | HAEGTFTSDVS acetate | PF-06882961 Tris | GLP-1(28-36)amide acetate | HAEGTFT acetate(926018-95-3 free base) | HAEGTFTSD acetate(926018-45-3 free base) | GLP-1 receptor agonist 9 citrate
相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Inhibitor Library | Bioactive Compound Library
Bioactivity
英文名: L-168049
描述: L-168049 是一种选择性和非竞争性人胰高血糖素受体拮抗剂，对人、鼠和犬的 IC50 分别为 3.7 nM、63 nM 和 60 nM。
体外活性: In Chinese hamster ovary cells expressing the human glucagon receptor, L-168049 increases the apparent EC50 of glucagon-stimulated adenylate cyclase and decreases maximal glucagon stimulation with a Kb of 25 nM[1]. L-168049 blocks glucagon-stimulated cAMP formation in mouse liver membrane and inhibits glucagon (100 pM)-stimulated cAMP synthesis in CHO cells expressing the human glucagon receptor with IC50 of 41 nM [3].
体内活性: 在L-G6pc-/-小鼠的肝脏中，L-168049（每千克体重50毫克；经口给药）在6小时内将Pck1 mRNA表达量减少了一半。L-168049阻止了肾脏和肠道中G6pc表达量的增加[2]。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Ethanol : 3.4mM
DMSO : insoluble
关键字: L-168049 | L168049 | L 168049
相关产品: Lixisenatide acetate (320367-13-3 free base) | GLP-1(7-36), amide | Adomeglivant | Oxyntomodulin acetate | HAEGTFTSDVS acetate | PF-06882961 Tris | GLP-1(28-36)amide acetate | HAEGTFT acetate(926018-95-3 free base) | HAEGTFTSD acetate(926018-45-3 free base) | GLP-1 receptor agonist 9 citrate
相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Inhibitor Library | Bioactive Compound Library
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