Product Introduction
Bioactivity


英文名: MIRA-1

描述: MIRA-1 (WRN Helicase Inhibitor) 是马来酰亚胺类似物。它可以恢复p53依赖的转录转激活诱导 p53 突变细胞凋亡，具有抗肿瘤作用。

体外活性: MIRA-1通过诱导p53的转录激活，包括p21、MDM2和PUMA的转录，从而在体外以IC50为10μM的条件下，依赖于突变型p53的方式促进肿瘤细胞通过凋亡死亡[1]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 20 mg/mL(109.19 mM)
Ethanol : 20 mg/mL(109.19 mM)


关键字: inhibit | MDM-2/p53 | MIRA 1 | Apoptosis | NSC19630 | Inhibitor | H1299 | SKOV | MIRA-1 | MIRA1 | NSC-19630 | Anticancer | Saos-2

相关产品: Cerevisterol | PU-H71 HCl | Poly(A) polymerase | Methotrexate | Vidarabine | Deoxythymidine-5'-triphosphate trisodium | RNA polymerase II-IN-1 | H3B-968 | Phleomycin | Branaplam

相关库: Anti-Aging Compound Library | Pyroptosis Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Lung Cancer Compound Library | Anti-Colorectal Cancer Compound Library | Anti-Cancer Active Compound Library | DNA Damage & Repair Compound Library | Anti-Pancreatic Cancer Compound Library | Metabolism Compound Library | Bioactive Compound Library