化合物MIRA-1 T22980

Product Introduction
Bioactivity


英文名: MIRA-1

描述: MIRA-1 (WRN Helicase Inhibitor) 是马来酰亚胺类似物。它可以恢复p53依赖的转录转激活诱导 p53 突变细胞凋亡，具有抗肿瘤作用。

体外活性: MIRA-1通过诱导p53的转录激活，包括p21、MDM2和PUMA的转录，从而在体外以IC50为10μM的条件下，依赖于突变型p53的方式促进肿瘤细胞通过凋亡死亡[1]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 20 mg/mL(109.19 mM)
Ethanol : 20 mg/mL(109.19 mM)


关键字: inhibit | MDM-2/p53 | MIRA 1 | Apoptosis | NSC19630 | Inhibitor | H1299 | SKOV | MIRA-1 | MIRA1 | NSC-19630 | Anticancer | Saos-2

相关产品: Cerevisterol | PU-H71 HCl | Poly(A) polymerase | Methotrexate | Vidarabine | Deoxythymidine-5'-triphosphate trisodium | RNA polymerase II-IN-1 | H3B-968 | Phleomycin | Branaplam

相关库: Anti-Aging Compound Library | Pyroptosis Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Lung Cancer Compound Library | Anti-Colorectal Cancer Compound Library | Anti-Cancer Active Compound Library | DNA Damage & Repair Compound Library | Anti-Pancreatic Cancer Compound Library | Metabolism Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途