化合物Compound 401 T3586
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Product IntroductionBioactivity英文名: Compound 401描述: Compound 401 (2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one) 是一种可靶
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Product Introduction
Bioactivity
英文名: Compound 401
描述: Compound 401 (2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one) 是一种可靶向 mTOR 的合成 DNA-PK 抑制剂，IC50为0.28 μM。
体外活性: Compound 401 shows activity against mTOR (IC50 = 5.3 μM) but not p110α/p85α PI3K (IC50 > 100 μM). Treatment of cells with Compound 401 blocks the phosphorylation of sites modified by mTOR-Raptor and mTOR-Rictor complexes (ribosomal protein S6 kinase 1 Thr389 and Akt Ser473, respectively).
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 5.45 mg/mL (19.39 mM)
关键字: Compound 401 | DNA-PK | Compound401 | DNA-dependent protein kinase | Compound-401 | inhibit | Inhibitor
相关产品: LTURM34 | PIK-93 | STL127705 | IC 86621 | PIK-90 | PIK-75 hydrochloride | Onatasertib | PI-103 | LY294002 | KU-0060648
相关库: Anti-Aging Compound Library | Antioxidant Compound Library | Glycometabolism Compound Library | Glutamine Metabolism Compound Library | Neuronal Differentiation Compound Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Kinase Inhibitor Library | DNA Damage & Repair Compound Library | Metabolism Compound Library
Bioactivity
英文名: Compound 401
描述: Compound 401 (2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one) 是一种可靶向 mTOR 的合成 DNA-PK 抑制剂，IC50为0.28 μM。
体外活性: Compound 401 shows activity against mTOR (IC50 = 5.3 μM) but not p110α/p85α PI3K (IC50 > 100 μM). Treatment of cells with Compound 401 blocks the phosphorylation of sites modified by mTOR-Raptor and mTOR-Rictor complexes (ribosomal protein S6 kinase 1 Thr389 and Akt Ser473, respectively).
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 5.45 mg/mL (19.39 mM)
关键字: Compound 401 | DNA-PK | Compound401 | DNA-dependent protein kinase | Compound-401 | inhibit | Inhibitor
相关产品: LTURM34 | PIK-93 | STL127705 | IC 86621 | PIK-90 | PIK-75 hydrochloride | Onatasertib | PI-103 | LY294002 | KU-0060648
相关库: Anti-Aging Compound Library | Antioxidant Compound Library | Glycometabolism Compound Library | Glutamine Metabolism Compound Library | Neuronal Differentiation Compound Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Kinase Inhibitor Library | DNA Damage & Repair Compound Library | Metabolism Compound Library
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