Product Introduction
Bioactivity


英文名: SM1-71

描述: SM1-71 是一种有效的多靶点丙烯酰胺修饰的 TAK1 抑制剂，抑制 MKNK2、MAP2K1/2/3/4/6/7、GAK、AAK1、BMP2K、MAP3K7、MAPKAPK5、GSK3A/B、MAPK1/3、SRC、YES1、FGFR1、ZAK (MLTK)、MAP3K1、LIMK1 和 RSK2。SM1-71 可作为激酶探针，具有抗癌活性，抑制多种癌细胞系的增殖。

体外活性: Potently inhibiting the proliferation of H23 and Calu-6 non-small cell lung cancer cell lines in a concentration-dependent manner, SM1-71 (0.001-100 μM; 72 h) demonstrates its efficacy. Additionally, SM1-71 induces potent cytotoxicity within 72 hours, with nanomolar values for GR50 and negative GRmax values observed in eight of 11 cancer cell lines[1][2].

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (215.54 mM)


关键字: SM-1-71 | SM171 | SM1 71

相关产品: Fasudil hydrochloride | SBC-115076 | HTH-01-091 | PCSK9-IN-10 | Chymotrypsin | SGC-GAK-1 | Piceatannol | Cetraxate hydrochloride | SRPKIN-1 | CRT0066101 dihydrochloride(956121-30-5 free base)

相关库: Immunology/Inflammation Compound Library