化合物 SM1-71 T36680

Product Introduction
Bioactivity


英文名: SM1-71

描述: SM1-71 是一种有效的多靶点丙烯酰胺修饰的 TAK1 抑制剂，抑制 MKNK2、MAP2K1/2/3/4/6/7、GAK、AAK1、BMP2K、MAP3K7、MAPKAPK5、GSK3A/B、MAPK1/3、SRC、YES1、FGFR1、ZAK (MLTK)、MAP3K1、LIMK1 和 RSK2。SM1-71 可作为激酶探针，具有抗癌活性，抑制多种癌细胞系的增殖。

体外活性: Potently inhibiting the proliferation of H23 and Calu-6 non-small cell lung cancer cell lines in a concentration-dependent manner, SM1-71 (0.001-100 μM; 72 h) demonstrates its efficacy. Additionally, SM1-71 induces potent cytotoxicity within 72 hours, with nanomolar values for GR50 and negative GRmax values observed in eight of 11 cancer cell lines[1][2].

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (215.54 mM)


关键字: SM-1-71 | SM171 | SM1 71

相关产品: Fasudil hydrochloride | SBC-115076 | HTH-01-091 | PCSK9-IN-10 | Chymotrypsin | SGC-GAK-1 | Piceatannol | Cetraxate hydrochloride | SRPKIN-1 | CRT0066101 dihydrochloride(956121-30-5 free base)

相关库: Immunology/Inflammation Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途