CAY10760 T36703
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Product IntroductionBioactivity英文名: CAY10760描述: CAY10760 is an inhibitor of the protein-protein interaction between RAD51
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Product Introduction
Bioactivity
英文名: CAY10760
描述: CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2 (EC50= 19 μM in a cell-free competitive ELISA).1It decreases homologous recombination by 54% in wild-typeBRCA2-expressing BxPC-3 pancreatic cancer cells when used at a concentration of 20 μM. CAY10760 (20 μM) decreases proliferation of BxPC-3, as well as mutantBRCA2-expressing Capan-1, cancer cells when used alone or in combination with the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib .
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMF : 11 mg/mL
DMF:PBS (pH 7.2) (1:2) : 0.3 mg/mL
DMSO : 10 mg/mL
关键字: CAY10760 | CAY 10760 | CAY-10760
Bioactivity
英文名: CAY10760
描述: CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2 (EC50= 19 μM in a cell-free competitive ELISA).1It decreases homologous recombination by 54% in wild-typeBRCA2-expressing BxPC-3 pancreatic cancer cells when used at a concentration of 20 μM. CAY10760 (20 μM) decreases proliferation of BxPC-3, as well as mutantBRCA2-expressing Capan-1, cancer cells when used alone or in combination with the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib .
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMF : 11 mg/mL
DMF:PBS (pH 7.2) (1:2) : 0.3 mg/mL
DMSO : 10 mg/mL
关键字: CAY10760 | CAY 10760 | CAY-10760
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