Product Introduction
Bioactivity


英文名: Cyclic-di-GMP disodium

描述: Cyclic-di-GMP disodium (5GP-5GP disodium) 是细菌的第二信使，也是一种 STING 激动剂，参与原核生物的多种过程，包括生物膜的形成、运动、和细胞周期的进展。Cyclic-di-GMP disodium 对癌细胞显示出抗增殖活性，可诱导 CD4 受体表达升高和细胞周期停滞。Cyclic-di-GMP disodium 可用于癌研究癌症。

体外活性: Cyclic-di-GMP disodium (0.5-50 μM; 5 days) demonstrates inhibition of human colon cancer cell proliferation.[1]Cyclic-di-GMP disodium (0.5-50 μM; 5 days) induces a targeted increase in CD4 expression within Jurkat cells and triggers S-phase cell cycle arrest in the same cells.[2]

体内活性: Cyclic-di-GMP disodium (100 μg/per; i.v.; two sequential vaccinations 9 days apart) augments TriVax-induced immune responses against melanoma in mice and further amplifies the anti-tumor effects of TriVax.[3]

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 144.0 mg/mL (196.1 mM)


关键字: Cyclic-di-GMP | 5GP-5GP | Cyclic-di-GMP disodium | Cyclic di-GMP

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