Product IntroductionBioactivity英文名:
VGSC blocker-1描述: VGSC blocker-1 is a powerful small molecule that serves as a blocker for the neonatal isoform of the VGSC subtype known as Nav1.5 (nNav1.5). It effectively blocks INa peak currents by 34.9% at a concentration of 1 μM, and demonstrates a 0.3% inhibition of cell invasion at the same concentration in the MDA-MB-231 human breast cancer cell line, without compromising cell viability.
体外活性: VGSC blocker 1 (compound 1) (1.0 to 10 μM) inhibits human breast cancer cell line MDA-MB-231[1]. Cell Viability Assay[1]Cell Line: human breast cancer cell line MDA-MB-231 Concentration: 1.0 to 10μM Incubation Time: 24 hours Result: VGSC blocker 1 blocks INa peak currents 34.9% at 1 uMa and inhibits cell invasion 0.3% at 1 uM. These values are much higher than the concentrations required (0.1 μM and 1 μM) to produce significant nNav1.5 current blockade and cell invasion inhibition.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字:
VGSC blocker 1 |
VGSC blocker-1 |
VGSC blocker1