VGSC blocker-1 T39717
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 2230472-55-4 | ¥10,600.00 | 询底价 |
Product Introduction
Bioactivity
英文名: VGSC blocker-1
描述: VGSC blocker-1 is a powerful small molecule that serves as a blocker for the neonatal isoform of the VGSC subtype known as Nav1.5 (nNav1.5). It effectively blocks INa peak currents by 34.9% at a concentration of 1 μM, and demonstrates a 0.3% inhibition of cell invasion at the same concentration in the MDA-MB-231 human breast cancer cell line, without compromising cell viability.
体外活性: VGSC blocker 1 (compound 1) (1.0 to 10 μM) inhibits human breast cancer cell line MDA-MB-231[1]. Cell Viability Assay[1]Cell Line: human breast cancer cell line MDA-MB-231 Concentration: 1.0 to 10μM Incubation Time: 24 hours Result: VGSC blocker 1 blocks INa peak currents 34.9% at 1 uMa and inhibits cell invasion 0.3% at 1 uM. These values are much higher than the concentrations required (0.1 μM and 1 μM) to produce significant nNav1.5 current blockade and cell invasion inhibition.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: VGSC blocker 1 | VGSC blocker-1 | VGSC blocker1
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途