Product Introduction
Bioactivity


英文名: Gaultherin

描述: Gaultherin 是一种分离自 Gaultheria yunnanensis 中的天然水杨酸酯衍生物。它是一种非甾体类抗炎药，具有止痛和抗炎作用，与 Aspirin 相比没有胃溃疡作用。

体外活性: The synthesis of Gaultherin (1) and its analogs was carried out to provide 11 glycosides under phase-transfer catalytic conditions. METHODS AND RESULTS: The activities of all synthesized compounds were evaluated by nitric oxide production inhibitory assay in vitro. Methyl 2-O-(4-O-β-d-galactopyranosyl)-β-d-glucopyranosylbenzoate (5f) showed significantly anti-nociceptive and anti-inflammatory effects by the evaluation in vivo. Structure-activity relationships within these compounds were discussed.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (112.01 mM)


关键字: salicylate | NSAID | Gaultheria | yunnanensis | Gaultherin | Inhibitor | analgesic | anti-inflammatory | inhibit | non-steroidal

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