Product Introduction
Bioactivity


英文名: Ensitrelvir fumarate

描述: Ensitrelvir (S-217622) fumarate is a novel orally active inhibitor, targeting the SARS-CoV-2 3CL protease (IC50 = 13 nM). It demonstrates non-covalent and non-peptidic characteristics. This compound represents a pioneering advancement in the development of effective antiviral agents against the SARS-CoV-2 virus.

体外活性: In a cytopathic effect (cpe)-inhibition assay of SARS-CoV-2 infected VeroE6/TMPRSS2 cells, Ensitrelvir fumarate shows the EC 50 values are approximately 0.4 μM for both wild-type virus and Alpha, Beta, Gamma and Delta variants. EC 50 values for SARS-CoV and MERS-CoV were 0.21 and 1.4 μM respectively[1].

体内活性: Ensitrelvir fumarate dose-dependently inhibits intrapulmonary replication of SARS-CoV-2 in mice[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Ensitrelvir Fumarate | Ensitrelvir fumarate | S 217622 Fumarate | S217622 Fumarate | S-217622 Fumarate